"XXVII International Symposium on Morphological Sciences. CELL, TISSUE, ORGANS - EXPERIENCE, INNOVATION AND PROGRESS"

Dear colleagues, we announce that from May 27 to May 31, 2021, al-Farabi Kazakh National University will host an international symposium “XXVII International Symposium on Morphological Sciences. CELLS, FABRICS, ORGANS - EXPERIENCE, INNOVATION AND PROGRESS”. As a part of this symposium, a workshop (online) for young scientists will be held. In this regard we are pleased to invite students, undergraduates, and doctoral students of medical and biological specialties to be listeners in a workshop for young scientists.

All listeners can obtain a listener certificate by registering.

Registration link: http://www.isms2020.kz/index.php/young-scientists

ONLINE WORKSHOP FOR YOUNG SCIENTISTS 

Theme: Immunofluorescence analysis of DNA damage response protein p53-binding protein 1: molecular indicator of genomic instability in human carcinogenesis

Timing: 28 May 2021 03:00 PM Almaty 

Language: English

Zoom link: https://zoom.us/j/93630505950?pwd=UlhyK2p4N2NBSWd3Q3pwT1RMc280Zz09

Speaker: Zhanna Mussazhanova, MD, PhD, Assistant professor. Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University.

Plan of workshop

1. DNA damage and repair
2. Genomic stability: the guardians of the genome stability
3. Immunofluorescence analysis of 53BP1 expression attractive candidate biomarker to evaluate a presence of genomic instability.
   1. Laboratory technique guide: immunofluorescence

Brief review:

Defective DNA damage response (DDR) can result in genomic instability (GIN) and lead to the transformation into cancer. P53-binding protein 1 (53BP1) belongs to a family of evolutionarily conserved DDR proteins. Because 53BP1 molecules localize at the sites of DNA double-strand breaks (DSBs) and rapidly form nuclear foci, the presence of 53BP1 foci can be considered as a cytologic marker for endogenous DSBs reflecting GIN. And it has been well documented in vitro by immunofluorescence studies, that 53BP1 nuclear foci might serve as a valuable molecular marker of genomic instability during carcinogenesis of thyroid, skin and cervical tumors.