ON 1. To organize, plan and implement the process of basic scientific research in the research laboratories of the biomedical field, practical health care institutions, pharmacological and chrono-medical centers, higher educational institutions.
ON 2. Directly lead and develop a development strategy for biomedical organizations; plan, organize and coordinate the activities of biomedical structural divisions, make proposals for its improvement, bearing full responsibility for the consequences of decisions made.
ON 3. Analyze, evaluate and compare various theoretical concepts in the field of biomedical research and draw appropriate conclusions;
ON 4. To ensure the quality and effectiveness of selected modern scientific research methods, to use the descriptive, prognostic and normative aspects of statistical methods when processing the results of a biomedical experiment.
ON 5. Choose and effectively use modern research methodology, conduct independent scientific research, identify and solve theoretical and applied problems in the framework of modern scientific biomedical fields (physiology, cardiology, oncology, endocrinology, immunology, pharmacology, digital medicine, regenerative medicine, etc.) d.)
ON 6. Generate their own new scientific ideas, communicate their knowledge and ideas to the scientific community, expanding the boundaries of scientific knowledge in the field of biomedicine;
ON 7. Integrate the achievements of the natural sciences (physics, chemistry, mathematics, etc.) with biology and medicine, use the principles of construction and functioning of biological systems to improve and optimize technical devices, create new types of devices, automata and control systems in medicine.
ON 8. Develop physical, mechanical, pharmacological and non-pharmacological correction methods, recommend a set of measures to normalize the body’s metabolic processes, level the symptoms of pathological conditions and restore constancy of the internal environment of the body.
ON 9. Organize and conduct an examination of scientific projects in the field of biomedicine based on a high level of competence in biomedicine, work experience, knowledge of the law, specialist's understanding of expert assessment methods, ability to argue their opinions, listen to others' opinions and, if necessary, correct theirs.
ON 10. To comply with the fundamental principles of bioethical principles, legislative and regulatory documents that ensure a responsible attitude to wildlife, to make decisions in a particular situation in accordance with generally accepted humanistic, moral norms and principles of behavior.
ON 11. To apply new conceptual approaches and directions of development of pedagogical science in the context of the modern paradigm of education, to apply modern methods and techniques of teaching in the field of teaching biomedical Sciences, various methodological approaches to the educational process in higher education, to use in personal practice modern research tools and innovative technologies of translation of knowledge of the basic concepts of natural science and Biomedicine;
ON 12. To demonstrate originality and creativity in the implementation of activities in the biomedical and pedagogical fields and building the trajectory of their professional development throughout their professional career, providing high competitiveness, to make their own original contribution to the development of this specialty.
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PhD thesis writing and defence
- Number of credits: 12
- Type of control: Докторская диссертация
- Description: The main purpose of "PhD thesis writing and defence": of a doctoral dissertation is the formation of the doctoral students' ability to disclose the content of research work for the defense of the thesis.
During the study of course, doctoral student's should be competent in:
1. to substantiate the content of new scientifically grounded theoretical and experimental results that allow to solve a theoretical or applied problem or are a major achievement in the development of specific scientific directions;
2. explain the assessment of the completeness of the solutions to the tasks assigned, according to the specifics of the professional sphere of activity;
3. they can analyze alternative solutions for solving research and practical problems and assess the prospects for implementing these options;
4. apply the skills of writing scientific texts and presenting them in the form of scientific publications and presentations.
5. to plan and structure the scientific search, clearly highlight the research problem, develop a plan / program and methods for its study, formalize, in accordance with the requirements of the State Educational Establishment, the scientific and qualification work in the form of a thesis for a scientific degree Doctor of Doctor of Philosophy (PhD) on specialty «8D07502 – Standardization and certification (by industry)».
During the study of the discipline doctoral student will learn following aspects: Registration of documents for presentation of the thesis for defense. Information card of the dissertation and registration-registration card (in the format Visio 2003). Extract from the minutes of the meeting of the institution, in which the preliminary defense of the thesis took place. Cover letter to the Higher Attestation Commission. Expert conclusion on the possibility of publishing the author's abstract. Expert opinion on the possibility of publishing a dissertation. Minutes of the meeting of the counting commission. Bulletin for voting. A shorthand record of the meeting of the dissertational council. List of scientific papers. Response of the official opponent. A review of the leading organization. The recall of the scientific adviser.
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Academic writing
- Number of credits: 2
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: Aim of the subject: to develop practical skills of writing academic texts for doctoral students in order to present the results of their work in the form of reports, reviews, scientific reports and publications in rating publications indexed in Scopus with a non-zero SJR that meet the criteria of non-predatory publications. Within the discipline, doctoral students improve their skills in analyzing and presenting of scientific information in various forms (report, review, article); learn to structure, format, select the style and language of describing research results in order to publish research materials in the form of scientific articles in ranked scientific journals, taking into account the peculiarities of writing scientific articles in English; master the methodology of writing a doctoral dissertation; develop the methodology for writing and issuing research grants in priority areas in the field of biomedicine and related fields. Also, learn to create the design of scientific research in accordance with the ethical principles and norms of the scientific publication process.
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The molecular basis of carcinogenesis
- Number of credits: 5
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of discipline: formation of ideas about the causes and molecular mechanisms of transformation of normal animal cells into tumor cells. When studying the discipline, carcinogenic factors (chemical factors, physical factors, biological factors), their classification and mechanisms of action are considered. The course examines the main molecular mechanisms of cancer cell formation (genetic mutations of certain regulatory systems) and the process of malignancy (malignization); biological mechanisms of carcinogenesis: theory of four-stage carcinogenesis (initiation, promotion, stem line formation, tumor progression); biological features of tumor growth (atypism, growth autonomy, tumor cell kinetics, invasive tumor growth, metastasis, impact on the body - cancer cachexia). Methods for assessing the molecular and genetic status in cancer diseases are considered.
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Oncoimmunology
- Number of credits: 5
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is the formation of a holistic systemic idea of the formation of knowledge about changes at the molecular and subcellular levels that occur during the development of the tumor process, the influence of the tumor on the metabolic processes of the whole organism.
As a result of the internship, the doctoral candidate is able to:
1. to describe the systematized information about the main immunochemical phenomena underlying the anti-infective nonspecific resistance and specific immune response to cancer cells,
2. to study the methods of laboratory immunochemical analysis,
3. learn the principles of analyzing the data of immunochemical analysis and the formulation of an immunological diagnosis,
4. have an understanding of the methods of immunotherapy and immunoprophylaxis based on the main immunochemical phenomena (antigen-antibody reactions, cell adhesion reactions, cytokine regulation of immunogenesis, etc.).
5. be able to plan an immunochemical experiment and analyze its results.
Discipline "Oncoimmunology" is aimed at developing in future specialists the ability to master the knowledge of the general laws governing the development of the functioning of the immune system in cancer diseases.
When studying the discipline, the following aspects will be considered:
Introduction to oncoimmunology. Immune surveillance of human tumors. Experimental evidence of immune tumor editing in mouse models. Tumor antigens. The use of tumor antigens for diagnosis. Modern approaches to adoptive cell therapy. Cancer vaccines. Inflammation and cancer. Antibodies in cancer immunotherapy. Current advances in cancer therapy.
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Scientific Research methods
- Number of credits: 3
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: Aim of the subject: to form the ability to apply modern methods and methodologies of scientific research in the performance of doctoral dissertation work. This subject deals with methods and methodologies of scientific research; modern experimental approaches to scientific research of a doctoral student; stages and principles of planning a scientific experiment; features of using biological objects in a biomedical experiment and selection of modern chemical, mathematical, physical and biological research methods that can solve the aim of experimental work; experimental approaches to the study of biomedical objects at the molecular level; advances in the use of molecular methods in the study of biological objects; the specificity of computer simulation in scientific research; rules for the implementation of the experiment, processing and interpretation of results.
Data for 2021-2024 years
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Biomarkers of oxidative stress and its diagnostic value
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is to form a holistic system view for doctoral candidates for the critical analysis and evaluation of modern scientific achievements in the field of oxidative stress as a preclinical stage of diagnosis.
As a result of studying the discipline, the doctoral candidate will be able to:
1. form an understanding of the nature of oxidative stress;
2. to systematize knowledge about the mechanisms of oxidative stress, about the molecules formed during oxidation;
3. use knowledge in the field of biological chemistry at a high theoretical level;
4. the ability and willingness to conduct basic scientific research in the field of biology and medicine;
5. analyze the skills of conducting experimental research using quantitative determination of oxidative stress biomarkers.
The discipline "Biomarkers of oxidative stress and its diagnostic value" is aimed at the formation of future specialists ' ability to study modern ideas about oxidative stress in General.
In the study of the discipline will consider the following aspects:
Problems of oxidative stress and endogenous intoxication in clinical practice, monitoring and methods of antioxidant correction. Problems of endogenous intoxication in clinical practice, the relationship with the processes of free radical oxidation, diagnostic methods. 0kislitelny stress— concept, pathophysiological and physiological aspects. Cytotoxic effects of reactive oxygen species. Physiological effects of reactive oxygen species. Antioxidant system of the body. Factors of non-enzymatic antioxidant protection. The enzyme link of the antioxidant system. Indicators of prooxidant link in various pathological conditions. Integrated methods of diagnostics of oxidative stress.
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Melatonin and metabolic syndrome
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is the formation of doctoral holistic systems representation of the formation of the ability to critically analyze and evaluate modern scientific advances on the role of melatonin in the metabolic syndrome and its importance as a diagnostic and prognostic marker.
As a result of studying the discipline, the doctoral candidate will be able to:
1. streamline their knowledge of modern ideas and scientific advances on the role of melatonin in the human body;
2. describe the mechanisms of regulation of metabolic processes;
3. analyze their understanding of the pathophysiological mechanisms of the metabolic syndrome;
4. describe the mechanisms of complex protective effects of melatonin in the development of the metabolic syndrome;
5. to study the role and place of clinical endocrinology and diabetology in the development of theoretical and practical medicine.
The discipline “Melatonin and metabolic syndrome” is aimed at developing the ability of future specialists to play the role of melatonin in metabolic syndrome and its importance for the human body.
When studying the discipline, the following aspects will be considered:
Factors affecting the development of metabolic syndrome. Diagnosis of metabolic syndrome in hospitals and specialized clinics. Features of the correction of dyshormonal risk factors for metabolic syndrome in women. Treatment of androgen deficiency in men with metabolic syndrome. Metabolic syndrome in children and adolescents.
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Mechanisms of apoptosis and necrosis
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is the formation of a holistic systemic representation of doctoral students in the field of research into the mechanisms of cell death.
As a result of studying the discipline, the doctoral candidate will be able to:
1. know the features of the paths of programmed cell death;
2. describe the molecular mechanisms of programmed cell death, its role in the development of pathologies (carcinogenesis and autoimmune diseases);
3. explain their causes and developmental mechanism, determine the distinctive morphological signs of apoptosis, necrosis and autophagy at the biochemical level, at the light-optical and ultrastructural levels;
4. assess their likely outcome and determine the significance of these processes for the organism;
5. use the knowledge gained for the formulation, conduct and interpretation of the results of experimental work.
The discipline "Mechanisms of apoptosis and necrosis" is aimed at developing the ability of future specialists to explain the causes and mechanisms of the development of cell death.
When studying the discipline, the following aspects will be considered: Electron-microscopic methods for determining the mechanisms of apoptosis and necrosis. The role of apoptosis in a multicellular organism: genetics, biochemistry, molecular mechanisms. Types and mechanisms of autophagy. Clinical characteristics of necrosis. Necrosis and apoptosis are similarities and differences. Biochemistry of handicap cell death.
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Free radicals and antioxidants
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is the formation of a holistic systemic understanding of the role of free radicals and antioxidants in solving basic problems occurring during physiological and pathological processes.
As a result of studying the discipline, the doctoral candidate will be able to:
1. understand the features of generating free radicals;
2. to study the main types of reactions of free organic radicals; the relationship between the structure and the reactivity of organic radicals
3. describe the main mechanisms of damage to biomolecules during oxidative stress and the occurrence of diseases of free radical etiology, principles of antioxidant protection of the body
4. be able to choose the necessary research methods, modify existing ones and develop new methods based on the objectives of a specific study;
5. be able to formulate and solve problems arising in the course of research activities and require in-depth professional knowledge.
Discipline "Free radicals and antioxidants" is aimed at the formation of future specialists about the role of free radicals and antioxidants in pathological processes occurring in the human body.
When studying the discipline, the following aspects will be considered:
The formation of free radicals and their effects on the body. General ideas about the process of lipid oxidation. Modern ideas about lipid auto-oxidation. Inhibition of oxidation with antioxidants. Antioxidants. Classification of antioxidants. Antioxidants phenolic nature. The biological role of natural antioxidants. Mechanisms of antioxidant activity. The use of antioxidants. Requirements for antioxidants.
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Cell pathology
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is to form a holistic systemic understanding of the manifestations and main mechanisms of cell damage in doctoral candidates
As a result of studying the discipline, the doctoral candidate will be able to:
1. explain the pathogenesis of individual manifestations of cell damage
2. describe the specific and non-specific manifestations of cell damage;
3. know the basic cell damage;
4. to study the factors affecting the permeability of the membrane
5. explain the pathogenetic role of calcium in the mechanisms of cell damage.
Discipline "Pathology of the cell" is aimed at developing the ability of future specialists to present information about the main mechanisms of cell damage in living organisms.
When studying the discipline, the following aspects will be considered:
Definition of cell damage. Types of cell damage. Adaptation of cells under the action of damaging agents. Apoptosis and cell necrosis. Morphological and functional signs of cell damage. Causes of cell damage. General mechanisms of cell damage. Mitochondrial damage and ATP depletion. The mechanism of cell damage by calcium ions.
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Modern methods of biomedical research
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is the formation of a holistic system view of doctoral students for the critical analysis and evaluation of modern methods of biomedical research on living organisms.
As a result of studying the discipline, the doctoral candidate will be able to:
1. know the basic experimental techniques used in biomedical research on living objects;
2. highlight the specific physical content in the applied tasks of future activities;
3. choose a research methodology adequate to the research objectives;
4. be able to describe the features of data acquisition in living organisms, the principles of their interpretation and analysis;
5. independently acquire new knowledge in this discipline, analyze it, apply this knowledge in practice and in the study of other disciplines.
The discipline "Modern methods of biomedical research" is aimed at developing among future specialists an approach and evaluation of modern methods of biomedical research on living organisms.
When studying the discipline, the following aspects will be considered:
Classification and review of modern methods of non-invasive research on living objects. Features of research on living organisms. Classification and review of modern methods of non-invasive research on living objects Ensuring patient safety and maintaining the vital activity of experimental animals. The study of physiological processes by magnetic resonance. Positron emission tomography and single photon emission computed tomography and other imaging techniques in biomedical research.
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Data analysis and computer methods of biomedicine
- Type of control: [RK1+MT+RK2+Exam] (100)
- Description: The purpose of the discipline is to form a holistic system representation of the ability of doctoral students to critically analyze and evaluate modern scientific achievements in the field of computer research methods and perform statistical processing of the results of observations on biological objects using standard tools of the Microsoft Office Excel program.
As a result of studying the discipline, the doctoral student will be able to:
1. understand the nature and importance of information in the development of modern society; owns the main methods, methods and means of receiving, storing, processing information;
2. streamline the theoretical knowledge of modern scientific achievements in the field of computer research methods;
3. use the latest statistical methods of processing the results of biological objects;
4. be able to use the appropriate mathematical apparatus and tools for processing, analyzing and systematizing information on the research topic;
5. independently acquire the skills of critical analysis and evaluation of modern scientific achievements and the results of activities in solving research and practical problems, including in interdisciplinary areas.
The discipline “Data Analysis and Computer Methods of Biomedicine” is aimed at developing among future specialists to consolidate the necessary knowledge for the relevant analysis and evaluation of modern scientific achievements in the field of computer methods of research and implementation of statistical methods for processing results.
When studying the discipline, the following aspects will be considered:
Difficulties in applying classical statistics to biological data. Statistics as the generally accepted rules for the unification and comparison of results. Statistics and material collection planning. Statistics and biological meaning, validity of the study. Modern level of education of biologists in the field of statistical data analysis. Stages of the study: work planning, data collection, sampling and primary processing (grouping, selection of primary data), statistical analysis, interpretation of results. The logic of working with databases. Differences between DBMS (Database Management Systems) on the example of Microsoft Access from Microsoft Excel spreadsheets.
Data for 2021-2024 years
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Pedagogical
- Type of control: Защита практики
- Description: Aim оf discipline: formation of the ability to carry out educational activities in universities, to design the educational process and conduct certain types of training sessions using innovative educational technologies.
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Research
- Type of control: Защита практики
- Description: The purpose of the practice: gaining experience in the study of an actual scientific problem, expand the professional knowledge gained in the learning process, and developing practical skills for conducting independent scientific work. The practice is aimed at developing the skills of research, analysis and application of economic knowledge.
Data for 2021-2024 years
